Assay Detail
Binding
CHEMBL4681206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alphaVbeta5 in human MCF7 cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.80 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289604 | — | — | 1 | 8.29 |
| CHEMBL4461771 | — | — | 1 | 6.42 |
| CHEMBL3289605 | — | — | 1 | 6.30 |
| CHEMBL4764510 | — | — | 1 | 6.17 |
| CHEMBL3289606 | — | — | 1 | - |
| CHEMBL4777693 | — | — | 1 | - |
| CHEMBL4794300 | — | — | 1 | - |
| CHEMBL4782288 | — | — | 1 | - |
| CHEMBL4797755 | — | — | 1 | - |
| CHEMBL4755971 | — | — | 1 | - |
| CHEMBL4461668 | — | — | 1 | - |
| CHEMBL4743438 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289604 | — | EC50 | = | 5.09 | nM | 8.29 |
| CHEMBL4461771 | — | EC50 | = | 376.0 | nM | 6.42 |
| CHEMBL3289605 | — | EC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4764510 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3289606 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4777693 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4794300 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4782288 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4797755 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4755971 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4461668 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4743438 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL88478 | — | EC50 | - | — | - | |
| CHEMBL916 | TIROFIBAN | EC50 | - | — | - |