Assay Detail
Binding
CHEMBL4681209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at alphaVbeta6 in human HT-29 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.39 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764510 | — | — | 1 | 7.35 |
| CHEMBL411941 | CYCLORGDFV | — | 1 | 5.43 |
| CHEMBL3289606 | — | — | 1 | - |
| CHEMBL4777693 | — | — | 1 | - |
| CHEMBL4794300 | — | — | 1 | - |
| CHEMBL4782288 | — | — | 1 | - |
| CHEMBL4797755 | — | — | 1 | - |
| CHEMBL4461771 | — | — | 1 | - |
| CHEMBL4755971 | — | — | 1 | - |
| CHEMBL4461668 | — | — | 1 | - |
| CHEMBL3289605 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL2418221 | — | — | 1 | - |
| CHEMBL238484 | — | — | 1 | - |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | - |
| CHEMBL4743438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764510 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 3696.0 | nM | 5.43 |
| CHEMBL3289606 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4777693 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4794300 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4782288 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4797755 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4461771 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4755971 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4461668 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3289605 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2418221 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL238484 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL88478 | — | IC50 | - | — | - | |
| CHEMBL916 | TIROFIBAN | IC50 | - | — | - | |
| CHEMBL4743438 | — | IC50 | > | 5000.0 | nM | - |