Assay Detail
Binding
CHEMBL4681218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-24 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.03 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289605 | — | — | 1 | 8.92 |
| CHEMBL411941 | CYCLORGDFV | — | 1 | 8.85 |
| CHEMBL4461771 | — | — | 1 | 8.72 |
| CHEMBL3289604 | — | — | 1 | 8.25 |
| CHEMBL4794300 | — | — | 1 | 8.00 |
| CHEMBL4764510 | — | — | 1 | 6.94 |
| CHEMBL4461668 | — | — | 1 | 6.54 |
| CHEMBL4777693 | — | — | 1 | - |
| CHEMBL4797755 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289605 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4461771 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3289604 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4794300 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4764510 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4461668 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4777693 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4797755 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4589062 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4586928 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL916 | TIROFIBAN | IC50 | - | — | - |