Assay Detail
Functional
CHEMBL4681291
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Cytotoxicity in HREC assessed as reduction in cell viability incubated for 48 hrs by MTT assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HREC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.25 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 5.54 |
| CHEMBL4747257 | — | — | 2 | 4.96 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | — | 2 | - |
| CHEMBL109 | VALPROIC ACID | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 2910.72 | nM | 5.54 |
| CHEMBL4747257 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4747257 | — | IC50 | = | 11066.24 | nM | 4.96 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | IC50 | = | 128200.0 | nM | - |
| CHEMBL1036 | HYDROXYHALOPERIDOL | IC50 | = | 128233.06 | nM | - |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 1449000.0 | nM | - |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 1448771.85 | nM | - |