Assay Detail
Functional
CHEMBL4681322
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Cytotoxicity in IL-3-dependent mouse 32D cells expressing Bcr-Abl after 3 days by WST-1 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 32D |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.03 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749381 | — | — | 1 | 6.19 |
| CHEMBL4757635 | — | — | 1 | 6.06 |
| CHEMBL4758532 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749381 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4757635 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4758532 | — | EC50 | = | 1400.0 | nM | 5.85 |