Assay Detail
Binding
CHEMBL4681609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig brain tubulin polymerization incubated for 20 mins by spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.51 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.88 |
| CHEMBL4285231 | — | — | 1 | 5.46 |
| CHEMBL4793994 | — | — | 1 | 5.18 |
| CHEMBL4762438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4285231 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4793994 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4762438 | — | IC50 | > | 100000.0 | nM | - |