Assay Detail
Functional
CHEMBL4681676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-HEP1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.60 |
| CHEMBL1163081 | LEUSA | — | 1 | 6.27 |
| CHEMBL4104169 | — | — | 1 | 5.25 |
| CHEMBL4558130 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1163081 | LEUSA | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4104169 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL4558130 | — | IC50 | = | 6810.0 | nM | 5.17 |