Assay Detail
Binding
CHEMBL4681817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of protein interaction between beta-catenin K181A mutant (unknown origin)/N-terminal biotinylated human BCL9 ( 350 to 375 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.49 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583576 | — | — | 1 | 5.77 |
| CHEMBL4762534 | — | — | 1 | 5.39 |
| CHEMBL4462309 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583576 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4762534 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL4462309 | — | Ki | = | 4900.0 | nM | 5.31 |