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Assay Detail

CHEMBL4681820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Zhang M,Wang Z,Zhang Y,Guo W,Ji H
J Med Chem (2018) 61 : 2989 -3007
PubMed 29566337 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.30 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4454758 1 5.85
CHEMBL4549859 1 5.68
CHEMBL4074243 1 5.64
CHEMBL4741350 1 5.64
CHEMBL4583576 1 5.55
CHEMBL4526556 1 5.51
CHEMBL4578352 1 5.51
CHEMBL4782234 1 5.51
CHEMBL4740432 1 5.47
CHEMBL4474227 1 5.44
CHEMBL4744819 1 5.39
CHEMBL4749367 1 4.82
CHEMBL4762534 1 4.14
CHEMBL4462309 1 4.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4454758 IC50 = 1400.0 nM 5.85
CHEMBL4549859 IC50 = 2100.0 nM 5.68
CHEMBL4074243 IC50 = 2300.0 nM 5.64
CHEMBL4741350 IC50 = 2300.0 nM 5.64
CHEMBL4583576 IC50 = 2800.0 nM 5.55
CHEMBL4526556 IC50 = 3100.0 nM 5.51
CHEMBL4578352 IC50 = 3100.0 nM 5.51
CHEMBL4782234 IC50 = 3100.0 nM 5.51
CHEMBL4740432 IC50 = 3400.0 nM 5.47
CHEMBL4474227 IC50 = 3600.0 nM 5.44
CHEMBL4744819 IC50 = 4100.0 nM 5.39
CHEMBL4749367 IC50 = 15000.0 nM 4.82
CHEMBL4762534 IC50 = 73000.0 nM 4.14
CHEMBL4462309 IC50 = 92000.0 nM 4.04