Assay Detail
Functional
CHEMBL4682406
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Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.36 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788683 | — | — | 1 | 8.66 |
| CHEMBL4792262 | — | — | 1 | 8.51 |
| CHEMBL4780030 | — | — | 1 | 8.24 |
| CHEMBL4751325 | — | — | 1 | 8.10 |
| CHEMBL4757130 | — | — | 1 | 8.03 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL4782980 | — | — | 1 | 7.75 |
| CHEMBL4790818 | — | — | 1 | 7.71 |
| CHEMBL4740396 | — | — | 1 | 7.68 |
| CHEMBL4764093 | — | — | 1 | 7.67 |
| CHEMBL4783901 | — | — | 1 | 7.51 |
| CHEMBL4752138 | — | — | 1 | 7.45 |
| CHEMBL4759262 | — | — | 1 | 7.38 |
| CHEMBL4796100 | — | — | 1 | 7.29 |
| CHEMBL4764578 | — | — | 1 | 7.16 |
| CHEMBL4747966 | — | — | 1 | 7.13 |
| CHEMBL4782405 | — | — | 1 | 7.12 |
| CHEMBL4755594 | — | — | 1 | 6.97 |
| CHEMBL4762356 | — | — | 1 | 6.95 |
| CHEMBL4780272 | — | — | 1 | 6.90 |
| CHEMBL4789506 | — | — | 1 | 6.86 |
| CHEMBL4740010 | — | — | 1 | 6.82 |
| CHEMBL4761287 | — | — | 1 | 6.81 |
| CHEMBL4788977 | — | — | 1 | 6.80 |
| CHEMBL4792674 | — | — | 1 | 6.75 |
| CHEMBL4745841 | — | — | 1 | 6.75 |
| CHEMBL4740677 | — | — | 1 | 6.73 |
| CHEMBL4751463 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788683 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4792262 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4780030 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4751325 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4757130 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4782980 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4790818 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL4740396 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4764093 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL4783901 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL4752138 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL4759262 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL4796100 | — | IC50 | = | 50.7 | nM | 7.29 |
| CHEMBL4764578 | — | IC50 | = | 68.8 | nM | 7.16 |
| CHEMBL4747966 | — | IC50 | = | 74.6 | nM | 7.13 |
| CHEMBL4782405 | — | IC50 | = | 76.1 | nM | 7.12 |
| CHEMBL4755594 | — | IC50 | = | 106.7 | nM | 6.97 |
| CHEMBL4762356 | — | IC50 | = | 111.3 | nM | 6.95 |
| CHEMBL4780272 | — | IC50 | = | 124.6 | nM | 6.90 |
| CHEMBL4789506 | — | IC50 | = | 137.8 | nM | 6.86 |
| CHEMBL4740010 | — | IC50 | = | 151.7 | nM | 6.82 |
| CHEMBL4761287 | — | IC50 | = | 153.4 | nM | 6.81 |
| CHEMBL4788977 | — | IC50 | = | 159.1 | nM | 6.80 |
| CHEMBL4792674 | — | IC50 | = | 179.79 | nM | 6.75 |
| CHEMBL4745841 | — | IC50 | = | 179.8 | nM | 6.75 |
| CHEMBL4740677 | — | IC50 | = | 186.6 | nM | 6.73 |
| CHEMBL4751463 | — | IC50 | = | 434.6 | nM | 6.36 |