Assay Detail
Binding
CHEMBL4682730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted 4-phenylthiazoles: Development of potent and selective A, A and dual A/A adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 5.85 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391834 | — | — | 1 | 8.56 |
| CHEMBL1316674 | — | — | 1 | 6.73 |
| CHEMBL52333 | ROLOFYLLINE | 3.0 | 1 | 6.53 |
| CHEMBL589080 | — | — | 1 | 5.50 |
| CHEMBL1625681 | — | — | 1 | 5.43 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.04 |
| CHEMBL1562432 | — | — | 1 | 4.52 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.47 |
| CHEMBL4780555 | — | — | 1 | - |
| CHEMBL111545 | — | — | 1 | - |
| CHEMBL4757397 | — | — | 1 | - |
| CHEMBL4763881 | — | — | 1 | - |
| CHEMBL4746936 | — | — | 1 | - |
| CHEMBL4796077 | — | — | 1 | - |
| CHEMBL4797325 | — | — | 1 | - |
| CHEMBL4745527 | — | — | 1 | - |
| CHEMBL4758461 | — | — | 1 | - |
| CHEMBL4752438 | — | — | 1 | - |
| CHEMBL4747947 | — | — | 1 | - |
| CHEMBL4797181 | — | — | 1 | - |
| CHEMBL4790122 | — | — | 1 | - |
| CHEMBL4795542 | — | — | 1 | - |
| CHEMBL4755914 | — | — | 1 | - |
| CHEMBL1242892 | — | — | 1 | - |
| CHEMBL1242426 | — | — | 1 | - |
| CHEMBL4787673 | — | — | 1 | - |
| CHEMBL1242247 | — | — | 1 | - |
| CHEMBL4764086 | — | — | 1 | - |
| CHEMBL4784975 | — | — | 1 | - |
| CHEMBL4779033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391834 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL1316674 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL52333 | ROLOFYLLINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL589080 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1625681 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 9070.0 | nM | 5.04 |
| CHEMBL1562432 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL113 | CAFFEINE | Ki | = | 33800.0 | nM | 4.47 |
| CHEMBL4757397 | — | Ki | > | 100.0 | nM | - |
| CHEMBL592679 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4763881 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4746936 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4796077 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4797325 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4745527 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4758461 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4752438 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4747947 | — | Ki | > | 100.0 | nM | - |
| CHEMBL111545 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4780555 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4797181 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4790122 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4795542 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4755914 | — | Ki | > | 100.0 | nM | - |
| CHEMBL1242892 | — | Ki | > | 100.0 | nM | - |
| CHEMBL1242426 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4787673 | — | Ki | > | 100.0 | nM | - |
| CHEMBL1242247 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4764086 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4784975 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4779033 | — | Ki | > | 100.0 | nM | - |