Assay Detail
Functional
CHEMBL4683196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.82 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798007 | — | — | 1 | 5.89 |
| CHEMBL4791122 | — | — | 1 | 5.85 |
| CHEMBL4745909 | — | — | 1 | 5.85 |
| CHEMBL4785329 | — | — | 1 | 5.80 |
| CHEMBL4462238 | — | — | 1 | 5.80 |
| CHEMBL4798881 | — | — | 1 | 5.77 |
| CHEMBL4748834 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798007 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4791122 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4745909 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4785329 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4462238 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4798881 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4748834 | — | IC50 | = | 1700.0 | nM | 5.77 |