Assay Detail
Functional
CHEMBL4683334
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Antimalarial activity against Plasmodium falciparum 3D7A asexual forms assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 24 hrs followed by [G-3H]hypoxanthine addition and measured after 18 hrs by liquid scintillation spectrometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.84 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.49 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.18 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL170 | QUININE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL506 | PRIMAQUINE | IC50 | > | 10000.0 | nM | - |