Assay Detail
Functional
CHEMBL4683336
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Antimalarial activity against Plasmodium falciparum 3D7 asexual forms incubated for 72 hrs by luminescence method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.75 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.57 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.36 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.33 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 4.35 | nM | 8.36 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.69 | nM | 8.33 |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 17900.0 | nM | 4.75 |