Assay Detail
Functional
CHEMBL4683363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against sulphadoxine-resistant blood stage Plasmodium falciparum 3D7 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 6.25 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752128 | — | — | 1 | 7.60 |
| CHEMBL4763185 | — | — | 1 | 7.41 |
| CHEMBL4742705 | — | — | 1 | 7.41 |
| CHEMBL3325608 | — | — | 1 | 7.39 |
| CHEMBL4758736 | — | — | 1 | 7.15 |
| CHEMBL4754454 | — | — | 1 | 7.06 |
| CHEMBL4785788 | — | — | 1 | 6.92 |
| CHEMBL4753957 | — | — | 1 | 6.92 |
| CHEMBL4740618 | — | — | 1 | 6.89 |
| CHEMBL4764796 | — | — | 1 | 6.89 |
| CHEMBL4740991 | — | — | 1 | 6.47 |
| CHEMBL4748442 | — | — | 1 | 6.32 |
| CHEMBL4777052 | — | — | 1 | 5.98 |
| CHEMBL4784939 | — | — | 1 | 5.83 |
| CHEMBL4783517 | — | — | 1 | 5.47 |
| CHEMBL4752250 | — | — | 1 | 5.46 |
| CHEMBL4756043 | — | — | 1 | 5.46 |
| CHEMBL4793940 | — | — | 1 | 5.45 |
| CHEMBL4754047 | — | — | 1 | 5.43 |
| CHEMBL4214320 | — | — | 1 | 5.41 |
| CHEMBL4204119 | — | — | 1 | 5.33 |
| CHEMBL4761677 | — | — | 1 | 5.33 |
| CHEMBL4744808 | — | — | 1 | 5.23 |
| CHEMBL4763641 | — | — | 1 | 5.11 |
| CHEMBL4760986 | — | — | 1 | - |
| CHEMBL4764951 | — | — | 1 | - |
| CHEMBL4755281 | — | — | 1 | - |
| CHEMBL4760448 | — | — | 1 | - |
| CHEMBL4755814 | — | — | 1 | - |
| CHEMBL4764114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752128 | — | EC50 | = | 25.1 | nM | 7.60 |
| CHEMBL4763185 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4742705 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3325608 | — | EC50 | = | 41.1 | nM | 7.39 |
| CHEMBL4758736 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4754454 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4785788 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4753957 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4740618 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4764796 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4740991 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4748442 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4777052 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4784939 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4783517 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4756043 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4752250 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4793940 | — | EC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4754047 | — | EC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4214320 | — | EC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL4204119 | — | EC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL4761677 | — | EC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL4744808 | — | EC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL4763641 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4799447 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4780054 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4799421 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4764114 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4755814 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4760448 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4755281 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4764951 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4760986 | — | EC50 | > | 10000.0 | nM | - |