Assay Detail
Binding
CHEMBL4683364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged Plasmodium falciparum 3D7 PI4K expressed in baculovirus infected Sf9 cells using PI:PS as substrate incubated for 1 hr in presence of ATP by ADP-Glo kinase assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum 3D7 |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.34 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4783517 | — | — | 1 | 9.40 |
| CHEMBL4754454 | — | — | 1 | 9.30 |
| CHEMBL4752128 | — | — | 1 | 9.05 |
| CHEMBL4785788 | — | — | 1 | 8.92 |
| CHEMBL4763185 | — | — | 1 | 8.92 |
| CHEMBL4758736 | — | — | 1 | 8.80 |
| CHEMBL3325608 | — | — | 1 | 8.80 |
| CHEMBL4742705 | — | — | 1 | 8.66 |
| CHEMBL4753957 | — | — | 1 | 8.64 |
| CHEMBL4756043 | — | — | 1 | 8.60 |
| CHEMBL4740991 | — | — | 1 | 8.35 |
| CHEMBL4204119 | — | — | 1 | 8.25 |
| CHEMBL4763641 | — | — | 1 | 8.12 |
| CHEMBL4214320 | — | — | 1 | 8.11 |
| CHEMBL4777052 | — | — | 1 | 8.09 |
| CHEMBL4793940 | — | — | 1 | 8.07 |
| CHEMBL4744808 | — | — | 1 | 8.06 |
| CHEMBL4784939 | — | — | 1 | 8.00 |
| CHEMBL4761677 | — | — | 1 | 7.90 |
| CHEMBL4748442 | — | — | 1 | 7.88 |
| CHEMBL4740618 | — | — | 1 | 7.86 |
| CHEMBL4752250 | — | — | 1 | 7.28 |
| CHEMBL4754047 | — | — | 1 | 6.84 |
| CHEMBL4764951 | — | — | 1 | - |
| CHEMBL4755281 | — | — | 1 | - |
| CHEMBL4760986 | — | — | 1 | - |
| CHEMBL4760448 | — | — | 1 | - |
| CHEMBL4755814 | — | — | 1 | - |
| CHEMBL4764114 | — | — | 1 | - |
| CHEMBL4799421 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4783517 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4754454 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4752128 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4785788 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4763185 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4758736 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3325608 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4742705 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4753957 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4756043 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4740991 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4204119 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4763641 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4214320 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4777052 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4793940 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4744808 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4784939 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4761677 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4748442 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4740618 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL4752250 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL4754047 | — | IC50 | = | 145.1 | nM | 6.84 |
| CHEMBL4764951 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4755281 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4760986 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4760448 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4755814 | — | IC50 | > | 40.0 | nM | - |
| CHEMBL4764114 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4799421 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4780054 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4764796 | — | IC50 | > | 156.0 | nM | - |
| CHEMBL4799447 | — | IC50 | > | 156.0 | nM | - |