Assay Detail
Functional
CHEMBL4683512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | INS1(832/13) |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 5.44 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4762000 | — | — | 1 | 6.70 |
| CHEMBL4646903 | — | — | 1 | 6.66 |
| CHEMBL4740109 | — | — | 1 | 6.57 |
| CHEMBL4776020 | — | — | 1 | 6.44 |
| CHEMBL4779489 | — | — | 1 | 6.43 |
| CHEMBL4740053 | — | — | 1 | 6.18 |
| CHEMBL4782328 | — | — | 1 | 6.02 |
| CHEMBL4780139 | — | — | 1 | 5.80 |
| CHEMBL4752211 | — | — | 1 | 5.78 |
| CHEMBL4758212 | — | — | 1 | 5.77 |
| CHEMBL4750959 | — | — | 1 | 5.76 |
| CHEMBL4798608 | — | — | 1 | 5.52 |
| CHEMBL4792552 | — | — | 1 | 5.42 |
| CHEMBL4763064 | — | — | 1 | 5.36 |
| CHEMBL4754143 | — | — | 1 | 5.34 |
| CHEMBL4755008 | — | — | 1 | 5.31 |
| CHEMBL1163488 | APOVINCAMINE | 2.0 | 1 | 5.30 |
| CHEMBL4747242 | — | — | 1 | 5.27 |
| CHEMBL4782985 | — | — | 1 | 5.26 |
| CHEMBL4764434 | — | — | 1 | 5.23 |
| CHEMBL4763968 | — | — | 1 | 5.17 |
| CHEMBL4798069 | — | — | 1 | 5.15 |
| CHEMBL4798410 | — | — | 1 | 5.14 |
| CHEMBL4642588 | — | — | 1 | 5.12 |
| CHEMBL4751578 | — | — | 1 | 5.06 |
| CHEMBL4788030 | — | — | 1 | 5.06 |
| CHEMBL4756288 | — | — | 1 | 5.04 |
| CHEMBL4796692 | — | — | 1 | 5.03 |
| CHEMBL4759428 | — | — | 1 | 4.99 |
| CHEMBL4790226 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4762000 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4646903 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4740109 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4776020 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4779489 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4740053 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4782328 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4780139 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4752211 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4758212 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4750959 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4798608 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4792552 | — | EC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL4763064 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4754143 | — | EC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL4755008 | — | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL1163488 | APOVINCAMINE | EC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4747242 | — | EC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL4782985 | — | EC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4764434 | — | EC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL4763968 | — | EC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4798069 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4798410 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4642588 | — | EC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL4751578 | — | EC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL4788030 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4756288 | — | EC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL4796692 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4759428 | — | EC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL4790226 | — | EC50 | = | 10180.0 | nM | 4.99 |
| CHEMBL4741314 | — | EC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL4755165 | — | EC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL1165342 | VINCAMINE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4761942 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4747522 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4762224 | — | EC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL4760086 | — | EC50 | = | 13170.0 | nM | 4.88 |