Assay Detail
Binding
CHEMBL4683694
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Inhibition of Saccharomyces cerevisiae alpha-glucosidase using maltose as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by LC-TQ-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.31 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289277 | EMODIN | — | 1 | 5.38 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 5.34 |
| CHEMBL42624 | PHYSCION | — | 1 | 5.27 |
| CHEMBL418068 | RHEIN | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289277 | EMODIN | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL42624 | PHYSCION | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL418068 | RHEIN | IC50 | = | 5680.0 | nM | 5.25 |