Assay Detail
Functional
CHEMBL4683896
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Phototoxicity against human QBC939 cells assessed as reduction in cell viability irradiated with 4 J/cm2 of 650 nanometer laser light preincubated for 24 hrs in dark and measured after 24 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | QBC939 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.08 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500576 | TEMOPORFIN | 4.0 | 1 | 6.20 |
| CHEMBL4778337 | — | — | 1 | 6.11 |
| CHEMBL4754261 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500576 | TEMOPORFIN | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4778337 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4754261 | — | IC50 | = | 1170.0 | nM | 5.93 |