Assay Detail
Binding
CHEMBL4684122
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Binding affinity to recombinant Influenza A virus (A/USA:Huston/AA/1945 H1N1)) N-terminal His6-tagged PA endonuclease assessed as dissociation constant by SPR analysis
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PA endonuclease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.58 | 9.68 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779680 | — | — | 1 | 9.68 |
| CHEMBL4748299 | — | — | 2 | 7.58 |
| CHEMBL4761767 | — | — | 2 | 7.03 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779680 | — | Kd | = | 0.2075 | nM | 9.68 |
| CHEMBL4748299 | — | Kd | = | 26.33 | nM | 7.58 |
| CHEMBL4761767 | — | Kd | = | 94.19 | nM | 7.03 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | Kd | = | 956.32 | nM | 6.02 |
| CHEMBL4748299 | — | Activity | - | — | - | |
| CHEMBL4761767 | — | Activity | - | — | - |