Assay Detail
Binding
CHEMBL4684411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.53 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790806 | — | — | 1 | 8.22 |
| CHEMBL4786073 | — | — | 1 | 8.06 |
| CHEMBL4784840 | — | — | 1 | 8.03 |
| CHEMBL4747175 | — | — | 1 | 7.78 |
| CHEMBL1775075 | — | — | 1 | 7.66 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL4785207 | — | — | 1 | 7.55 |
| CHEMBL4751980 | — | — | 1 | 7.53 |
| CHEMBL4760748 | — | — | 1 | 7.50 |
| CHEMBL4741017 | — | — | 1 | 7.50 |
| CHEMBL4741899 | — | — | 1 | 7.47 |
| CHEMBL4783101 | — | — | 1 | 7.42 |
| CHEMBL4762561 | — | — | 1 | 7.40 |
| CHEMBL4747714 | — | — | 1 | 7.35 |
| CHEMBL4747600 | — | — | 1 | 7.35 |
| CHEMBL4758858 | — | — | 1 | 7.34 |
| CHEMBL4798487 | — | — | 1 | 7.25 |
| CHEMBL4780776 | — | — | 1 | 7.19 |
| CHEMBL4782119 | — | — | 1 | 7.18 |
| CHEMBL4790351 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790806 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4786073 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL4784840 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4747175 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL1775075 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4785207 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL4751980 | — | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL4760748 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL4741017 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL4741899 | — | Ki | = | 33.5 | nM | 7.47 |
| CHEMBL4783101 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL4762561 | — | Ki | = | 40.1 | nM | 7.40 |
| CHEMBL4747714 | — | Ki | = | 44.3 | nM | 7.35 |
| CHEMBL4747600 | — | Ki | = | 44.9 | nM | 7.35 |
| CHEMBL4758858 | — | Ki | = | 45.7 | nM | 7.34 |
| CHEMBL4798487 | — | Ki | = | 56.3 | nM | 7.25 |
| CHEMBL4780776 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL4782119 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL4790351 | — | Ki | = | 67.6 | nM | 7.17 |