Assay Detail
Binding
CHEMBL4684412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.54 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL1775075 | — | — | 1 | 8.00 |
| CHEMBL4786073 | — | — | 1 | 7.96 |
| CHEMBL4741017 | — | — | 1 | 7.85 |
| CHEMBL4790351 | — | — | 1 | 7.84 |
| CHEMBL4785207 | — | — | 1 | 7.73 |
| CHEMBL4760748 | — | — | 1 | 7.59 |
| CHEMBL4784840 | — | — | 1 | 7.56 |
| CHEMBL4783101 | — | — | 1 | 7.51 |
| CHEMBL4790806 | — | — | 1 | 7.50 |
| CHEMBL4747175 | — | — | 1 | 7.44 |
| CHEMBL4741899 | — | — | 1 | 7.41 |
| CHEMBL4782119 | — | — | 1 | 7.37 |
| CHEMBL4798487 | — | — | 1 | 7.35 |
| CHEMBL4747714 | — | — | 1 | 7.31 |
| CHEMBL4747600 | — | — | 1 | 7.28 |
| CHEMBL4780776 | — | — | 1 | 7.26 |
| CHEMBL4762561 | — | — | 1 | 7.23 |
| CHEMBL4758858 | — | — | 1 | 7.22 |
| CHEMBL4751980 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1775075 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL4786073 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL4741017 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL4790351 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL4785207 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL4760748 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL4784840 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL4783101 | — | Ki | = | 30.6 | nM | 7.51 |
| CHEMBL4790806 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL4747175 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL4741899 | — | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL4782119 | — | Ki | = | 43.2 | nM | 7.37 |
| CHEMBL4798487 | — | Ki | = | 44.3 | nM | 7.35 |
| CHEMBL4747714 | — | Ki | = | 48.8 | nM | 7.31 |
| CHEMBL4747600 | — | Ki | = | 52.8 | nM | 7.28 |
| CHEMBL4780776 | — | Ki | = | 54.3 | nM | 7.26 |
| CHEMBL4762561 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL4758858 | — | Ki | = | 60.7 | nM | 7.22 |
| CHEMBL4751980 | — | Ki | = | 88.6 | nM | 7.05 |