Assay Detail
Binding
CHEMBL4684417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma33P]ATP
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.14 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 7.00 |
| CHEMBL4798487 | — | — | 1 | 5.19 |
| CHEMBL4780776 | — | — | 1 | 5.10 |
| CHEMBL4747714 | — | — | 1 | 4.94 |
| CHEMBL215205 | — | — | 1 | 4.70 |
| CHEMBL4784840 | — | — | 1 | 4.69 |
| CHEMBL1775075 | — | — | 1 | 4.38 |
| CHEMBL4747175 | — | — | 1 | - |
| CHEMBL4747600 | — | — | 1 | - |
| CHEMBL4760748 | — | — | 1 | - |
| CHEMBL4758858 | — | — | 1 | - |
| CHEMBL4790806 | — | — | 1 | - |
| CHEMBL4751980 | — | — | 1 | - |
| CHEMBL4785207 | — | — | 1 | - |
| CHEMBL4762561 | — | — | 1 | - |
| CHEMBL4741899 | — | — | 1 | - |
| CHEMBL4786073 | — | — | 1 | - |
| CHEMBL4741017 | — | — | 1 | - |
| CHEMBL4782119 | — | — | 1 | - |
| CHEMBL4783101 | — | — | 1 | - |
| CHEMBL4790351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4798487 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4780776 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4747714 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL215205 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4784840 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL1775075 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL4747175 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4747600 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4760748 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4758858 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4790806 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4751980 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4785207 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4762561 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4741899 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4786073 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4741017 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4782119 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4783101 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4790351 | — | IC50 | > | 12500.0 | nM | - |