Assay Detail
Functional
CHEMBL4684478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.18 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741899 | — | — | 1 | 6.02 |
| CHEMBL4782119 | — | — | 1 | 5.12 |
| CHEMBL4786073 | — | — | 1 | 5.11 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.04 |
| CHEMBL4741017 | — | — | 1 | 4.99 |
| CHEMBL4747714 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741899 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4782119 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL4786073 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4741017 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4747714 | — | IC50 | = | 15100.0 | nM | 4.82 |