Assay Detail
Binding
CHEMBL4684522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PRMT8 using histone H4 as substrate by hotspot assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.08 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 6.96 |
| CHEMBL4757320 | — | — | 1 | 4.27 |
| CHEMBL4755253 | — | — | 1 | 4.02 |
| CHEMBL4787257 | — | — | 1 | - |
| CHEMBL4777038 | — | — | 1 | - |
| CHEMBL4740900 | — | — | 1 | - |
| CHEMBL4765125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4757320 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL4755253 | — | IC50 | = | 94900.0 | nM | 4.02 |
| CHEMBL4787257 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL4777038 | — | IC50 | - | — | - | |
| CHEMBL4740900 | — | IC50 | - | — | - | |
| CHEMBL4765125 | — | IC50 | > | 250000.0 | nM | - |