Assay Detail
ADMET
CHEMBL4684533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 24 hrs by WST-1 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.85 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087454 | — | — | 1 | 5.30 |
| CHEMBL4754957 | — | — | 1 | 4.40 |
| CHEMBL4786260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087454 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4754957 | — | EC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4786260 | — | EC50 | >= | 40000.0 | nM | - |