Assay Detail
Binding
CHEMBL4684571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IDO1 expressed in HEK293T cells assessed as reduction in N-formylkynurenine production incubated for 12 hrs by microplate reader analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.13 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.02 |
| CHEMBL4783332 | — | — | 1 | 7.70 |
| CHEMBL4746161 | — | — | 1 | 7.37 |
| CHEMBL4740235 | — | — | 1 | 7.37 |
| CHEMBL4749003 | — | — | 1 | 7.30 |
| CHEMBL4761345 | — | — | 1 | 7.24 |
| CHEMBL4745884 | — | — | 1 | 7.16 |
| CHEMBL4779669 | — | — | 1 | 6.90 |
| CHEMBL4778450 | — | — | 1 | 6.86 |
| CHEMBL4740111 | — | — | 1 | 6.81 |
| CHEMBL4750297 | — | — | 1 | 6.75 |
| CHEMBL4750230 | — | — | 1 | 6.73 |
| CHEMBL4792825 | — | — | 1 | 6.48 |
| CHEMBL4777641 | — | — | 1 | - |
| CHEMBL4746720 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 9.63 | nM | 8.02 |
| CHEMBL4783332 | — | IC50 | = | 19.88 | nM | 7.70 |
| CHEMBL4746161 | — | IC50 | = | 42.58 | nM | 7.37 |
| CHEMBL4740235 | — | IC50 | = | 42.99 | nM | 7.37 |
| CHEMBL4749003 | — | IC50 | = | 49.83 | nM | 7.30 |
| CHEMBL4761345 | — | IC50 | = | 57.76 | nM | 7.24 |
| CHEMBL4745884 | — | IC50 | = | 68.59 | nM | 7.16 |
| CHEMBL4779669 | — | IC50 | = | 125.44 | nM | 6.90 |
| CHEMBL4778450 | — | IC50 | = | 137.95 | nM | 6.86 |
| CHEMBL4740111 | — | IC50 | = | 153.75 | nM | 6.81 |
| CHEMBL4750297 | — | IC50 | = | 177.35 | nM | 6.75 |
| CHEMBL4750230 | — | IC50 | = | 186.2 | nM | 6.73 |
| CHEMBL4792825 | — | IC50 | = | 333.65 | nM | 6.48 |
| CHEMBL4777641 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4746720 | — | IC50 | > | 1000.0 | nM | - |