Assay Detail
Binding
CHEMBL4684572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 30 mins by microplate reader analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.52 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.06 |
| CHEMBL4783332 | — | — | 1 | 6.96 |
| CHEMBL4790698 | — | — | 1 | 6.91 |
| CHEMBL4761345 | — | — | 1 | 6.86 |
| CHEMBL4741255 | — | — | 1 | 6.85 |
| CHEMBL4746161 | — | — | 1 | 6.83 |
| CHEMBL4751035 | — | — | 1 | 6.82 |
| CHEMBL4745884 | — | — | 1 | 6.75 |
| CHEMBL4759044 | — | — | 1 | 6.73 |
| CHEMBL4748208 | — | — | 1 | 6.61 |
| CHEMBL4750297 | — | — | 1 | 6.58 |
| CHEMBL4794436 | — | — | 1 | 6.45 |
| CHEMBL4749003 | — | — | 1 | 6.44 |
| CHEMBL4740111 | — | — | 1 | 6.44 |
| CHEMBL4779669 | — | — | 1 | 6.44 |
| CHEMBL4798048 | — | — | 1 | 6.44 |
| CHEMBL4778450 | — | — | 1 | 6.37 |
| CHEMBL4792825 | — | — | 1 | 6.35 |
| CHEMBL4779415 | — | — | 1 | 6.32 |
| CHEMBL4746720 | — | — | 1 | 6.32 |
| CHEMBL4777641 | — | — | 1 | 6.31 |
| CHEMBL4741499 | — | — | 1 | 6.29 |
| CHEMBL4740235 | — | — | 1 | 6.28 |
| CHEMBL4755628 | — | — | 1 | 6.23 |
| CHEMBL4791632 | — | — | 1 | 6.22 |
| CHEMBL4750230 | — | — | 1 | 6.14 |
| CHEMBL4759989 | — | — | 1 | 6.02 |
| CHEMBL4788193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 87.4 | nM | 7.06 |
| CHEMBL4783332 | — | IC50 | = | 108.7 | nM | 6.96 |
| CHEMBL4790698 | — | IC50 | = | 122.8 | nM | 6.91 |
| CHEMBL4761345 | — | IC50 | = | 139.1 | nM | 6.86 |
| CHEMBL4741255 | — | IC50 | = | 142.5 | nM | 6.85 |
| CHEMBL4746161 | — | IC50 | = | 146.4 | nM | 6.83 |
| CHEMBL4751035 | — | IC50 | = | 150.1 | nM | 6.82 |
| CHEMBL4745884 | — | IC50 | = | 178.1 | nM | 6.75 |
| CHEMBL4759044 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4748208 | — | IC50 | = | 245.2 | nM | 6.61 |
| CHEMBL4750297 | — | IC50 | = | 261.7 | nM | 6.58 |
| CHEMBL4794436 | — | IC50 | = | 357.8 | nM | 6.45 |
| CHEMBL4749003 | — | IC50 | = | 360.3 | nM | 6.44 |
| CHEMBL4740111 | — | IC50 | = | 359.7 | nM | 6.44 |
| CHEMBL4779669 | — | IC50 | = | 363.2 | nM | 6.44 |
| CHEMBL4798048 | — | IC50 | = | 364.1 | nM | 6.44 |
| CHEMBL4778450 | — | IC50 | = | 425.7 | nM | 6.37 |
| CHEMBL4792825 | — | IC50 | = | 443.3 | nM | 6.35 |
| CHEMBL4779415 | — | IC50 | = | 480.1 | nM | 6.32 |
| CHEMBL4746720 | — | IC50 | = | 476.9 | nM | 6.32 |
| CHEMBL4777641 | — | IC50 | = | 489.6 | nM | 6.31 |
| CHEMBL4741499 | — | IC50 | = | 517.2 | nM | 6.29 |
| CHEMBL4740235 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL4755628 | — | IC50 | = | 585.2 | nM | 6.23 |
| CHEMBL4791632 | — | IC50 | = | 601.9 | nM | 6.22 |
| CHEMBL4750230 | — | IC50 | = | 716.8 | nM | 6.14 |
| CHEMBL4759989 | — | IC50 | = | 959.5 | nM | 6.02 |
| CHEMBL4788193 | — | IC50 | > | 1000.0 | nM | - |