Assay Detail
Binding
CHEMBL4684595
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Displacement of [3H]-U69593 from human kappa opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.41 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290543 | — | — | 1 | 9.04 |
| CHEMBL4756256 | — | — | 1 | 7.31 |
| CHEMBL4786173 | — | — | 1 | 7.15 |
| CHEMBL4800532 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290543 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL4756256 | — | Ki | = | 49.1 | nM | 7.31 |
| CHEMBL4786173 | — | Ki | = | 71.38 | nM | 7.15 |
| CHEMBL4800532 | — | Ki | = | 718.6 | nM | 6.14 |