Assay Detail
Functional
CHEMBL4684606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human kappa opioid receptor expressed in CHO cells incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.76 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290543 | — | — | 1 | 8.56 |
| CHEMBL4786173 | — | — | 1 | 6.96 |
| CHEMBL38874 | DAMGO | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290543 | — | EC50 | = | 2.77 | nM | 8.56 |
| CHEMBL4786173 | — | EC50 | = | 110.4 | nM | 6.96 |
| CHEMBL38874 | DAMGO | EC50 | - | — | - | |
| CHEMBL31421 | — | EC50 | - | — | - | |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | EC50 | - | — | - |