Assay Detail
ADMET
CHEMBL4684790
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Cytotoxicity against mouse NIH/3T3 cells incubated for 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | 3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.35 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518383 | — | — | 1 | 5.61 |
| CHEMBL4761880 | — | — | 1 | 5.35 |
| CHEMBL4745240 | — | — | 1 | 5.33 |
| CHEMBL4087968 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518383 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4761880 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4745240 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL4087968 | — | IC50 | = | 7850.0 | nM | 5.11 |