Assay Detail
Binding
CHEMBL4684796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length CDK1/cyclin A2 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.83 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761880 | — | — | 1 | 5.06 |
| CHEMBL4745240 | — | — | 1 | 4.90 |
| CHEMBL518383 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761880 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL4745240 | — | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL518383 | — | IC50 | = | 29470.0 | nM | 4.53 |