Assay Detail
Binding
CHEMBL4685027
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Inhibition of full length human Akt1 S478G mutant using GRPRTSSFAEGKK as substrate incubated for 40 mins by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.26 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 7.72 |
| CHEMBL4757904 | — | — | 1 | 7.47 |
| CHEMBL4787195 | — | — | 1 | 7.41 |
| CHEMBL4745768 | — | — | 1 | 7.29 |
| CHEMBL4793499 | — | — | 1 | 6.90 |
| CHEMBL4781445 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4757904 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4787195 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4745768 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4793499 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4781445 | — | IC50 | = | 166.0 | nM | 6.78 |