Assay Detail
Binding
CHEMBL4685029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human Akt3 S472D mutant using GRPRTSSFAEGKK as substrate incubated for 40 mins by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 7.58 |
| CHEMBL4745768 | — | — | 1 | 7.35 |
| CHEMBL4787195 | — | — | 1 | 7.02 |
| CHEMBL4793499 | — | — | 1 | 7.00 |
| CHEMBL4757904 | — | — | 1 | 6.89 |
| CHEMBL4781445 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4745768 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4787195 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4793499 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4757904 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4781445 | — | IC50 | = | 137.0 | nM | 6.86 |