Assay Detail
Functional
CHEMBL4685033
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Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.11 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757904 | — | — | 1 | 6.41 |
| CHEMBL4787195 | — | — | 1 | 6.28 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 6.18 |
| CHEMBL4745768 | — | — | 1 | 6.01 |
| CHEMBL4793499 | — | — | 1 | 5.90 |
| CHEMBL4781445 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757904 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL4787195 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL4745768 | — | IC50 | = | 978.0 | nM | 6.01 |
| CHEMBL4793499 | — | IC50 | = | 1249.0 | nM | 5.90 |
| CHEMBL4781445 | — | IC50 | = | 1354.0 | nM | 5.87 |