Assay Detail
Binding
CHEMBL4685116
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Inhibition of HDAC in human HeLa cell nuclear extract using fluorescence substrate incubated for 30 mins by fluorescence based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.00 |
| CHEMBL4790152 | — | — | 1 | 6.70 |
| CHEMBL4789155 | — | — | 1 | 6.41 |
| CHEMBL4798549 | — | — | 1 | 6.28 |
| CHEMBL4790559 | — | — | 1 | 5.77 |
| CHEMBL4782478 | — | — | 1 | - |
| CHEMBL4749731 | — | — | 1 | - |
| CHEMBL4740842 | — | — | 1 | - |
| CHEMBL4741850 | — | — | 1 | - |
| CHEMBL4747757 | — | — | 1 | - |
| CHEMBL467399 | BIIB021 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 99.4 | nM | 7.00 |
| CHEMBL4790152 | — | IC50 | = | 198.9 | nM | 6.70 |
| CHEMBL4789155 | — | IC50 | = | 388.8 | nM | 6.41 |
| CHEMBL4798549 | — | IC50 | = | 521.4 | nM | 6.28 |
| CHEMBL4790559 | — | IC50 | = | 1683.0 | nM | 5.77 |
| CHEMBL4782478 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4749731 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4740842 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4741850 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4747757 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL467399 | BIIB021 | IC50 | > | 1000.0 | nM | - |