Assay Detail
Functional
CHEMBL4685246
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Cytotoxicity against human U87-TxR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U87-TxR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.12 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754210 | — | — | 1 | 5.22 |
| CHEMBL4739941 | — | — | 1 | 5.21 |
| CHEMBL4745896 | — | — | 1 | 5.21 |
| CHEMBL4791226 | — | — | 1 | 5.11 |
| CHEMBL4792536 | — | — | 1 | 5.11 |
| CHEMBL4793784 | — | — | 1 | 5.08 |
| CHEMBL4459518 | — | — | 1 | 5.07 |
| CHEMBL4786625 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754210 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL4739941 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL4745896 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL4791226 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL4792536 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL4793784 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL4459518 | — | IC50 | = | 8540.0 | nM | 5.07 |
| CHEMBL4786625 | — | IC50 | = | 11720.0 | nM | 4.93 |