Assay Detail
Binding
CHEMBL4685400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ketanserin from recombinant human 5HT2A receptor expressed in CHOK1 cell membranes measured after 1 hr by microbeta counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 8.78 | 9.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759492 | — | — | 1 | 9.61 |
| CHEMBL4753094 | — | — | 1 | 9.61 |
| CHEMBL4747225 | — | — | 1 | 9.61 |
| CHEMBL4763085 | — | — | 1 | 9.48 |
| CHEMBL4764006 | — | — | 1 | 9.46 |
| CHEMBL4754193 | — | — | 1 | 9.40 |
| CHEMBL4793608 | — | — | 1 | 9.38 |
| CHEMBL4785434 | — | — | 1 | 9.35 |
| CHEMBL4754138 | — | — | 1 | 9.35 |
| CHEMBL4748379 | — | — | 1 | 9.23 |
| CHEMBL4764468 | — | — | 1 | 9.13 |
| CHEMBL4751063 | — | — | 1 | 9.10 |
| CHEMBL4747978 | — | — | 1 | 9.10 |
| CHEMBL4744007 | — | — | 1 | 9.03 |
| CHEMBL4779739 | — | — | 1 | 8.99 |
| CHEMBL4782149 | — | — | 1 | 8.96 |
| CHEMBL4776225 | — | — | 1 | 8.96 |
| CHEMBL4762226 | — | — | 1 | 8.96 |
| CHEMBL4749824 | — | — | 1 | 8.89 |
| CHEMBL4784414 | — | — | 1 | 8.87 |
| CHEMBL4741142 | — | — | 1 | 8.81 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.72 |
| CHEMBL4780470 | — | — | 1 | 8.55 |
| CHEMBL4795995 | — | — | 1 | 8.50 |
| CHEMBL4778418 | — | — | 1 | 8.41 |
| CHEMBL4784228 | — | — | 1 | 8.38 |
| CHEMBL4750664 | — | — | 1 | 8.37 |
| CHEMBL4775997 | — | — | 1 | 8.28 |
| CHEMBL4760655 | — | — | 1 | 8.27 |
| CHEMBL4764557 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759492 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL4747225 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL4753094 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL4763085 | — | Ki | = | 0.3311 | nM | 9.48 |
| CHEMBL4764006 | — | Ki | = | 0.3467 | nM | 9.46 |
| CHEMBL4754193 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL4793608 | — | Ki | = | 0.4169 | nM | 9.38 |
| CHEMBL4754138 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL4785434 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL4748379 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL4764468 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL4751063 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL4747978 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL4744007 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL4779739 | — | Ki | = | 1.023 | nM | 8.99 |
| CHEMBL4782149 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL4762226 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL4776225 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL4749824 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL4784414 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL4741142 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL6437 | MIANSERIN | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL4780470 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL4795995 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL4778418 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL4784228 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL4750664 | — | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL4775997 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL4760655 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL4764557 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL4750587 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL4790020 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL4742856 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL4763106 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL4758402 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL4796647 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL4748107 | — | Ki | = | 19.5 | nM | 7.71 |