Assay Detail
Binding
CHEMBL4685402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.70 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 9.26 |
| CHEMBL4775997 | — | — | 1 | 8.84 |
| CHEMBL4750664 | — | — | 1 | 8.77 |
| CHEMBL4754138 | — | — | 1 | 8.77 |
| CHEMBL4784228 | — | — | 1 | 8.56 |
| CHEMBL4758402 | — | — | 1 | 8.40 |
| CHEMBL4795995 | — | — | 1 | 8.32 |
| CHEMBL4793608 | — | — | 1 | 8.30 |
| CHEMBL4763085 | — | — | 1 | 8.30 |
| CHEMBL4747225 | — | — | 1 | 8.26 |
| CHEMBL4759492 | — | — | 1 | 8.19 |
| CHEMBL4764006 | — | — | 1 | 8.16 |
| CHEMBL4753094 | — | — | 1 | 8.14 |
| CHEMBL4776225 | — | — | 1 | 8.14 |
| CHEMBL4742856 | — | — | 1 | 8.01 |
| CHEMBL4779739 | — | — | 1 | 7.89 |
| CHEMBL4782149 | — | — | 1 | 7.80 |
| CHEMBL4764468 | — | — | 1 | 7.74 |
| CHEMBL4754193 | — | — | 1 | 7.60 |
| CHEMBL4750587 | — | — | 1 | 7.59 |
| CHEMBL4741142 | — | — | 1 | 7.55 |
| CHEMBL4747978 | — | — | 1 | 7.53 |
| CHEMBL4796647 | — | — | 1 | 7.50 |
| CHEMBL4785434 | — | — | 1 | 7.42 |
| CHEMBL4749824 | — | — | 1 | 7.37 |
| CHEMBL4778418 | — | — | 1 | 7.19 |
| CHEMBL4784414 | — | — | 1 | 7.19 |
| CHEMBL4762226 | — | — | 1 | 7.03 |
| CHEMBL4744007 | — | — | 1 | 6.93 |
| CHEMBL4764557 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | Ki | = | 0.5495 | nM | 9.26 |
| CHEMBL4775997 | — | Ki | = | 1.445 | nM | 8.84 |
| CHEMBL4754138 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL4750664 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL4784228 | — | Ki | = | 2.754 | nM | 8.56 |
| CHEMBL4758402 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL4795995 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL4793608 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4763085 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4747225 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL4759492 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL4764006 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL4753094 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL4776225 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL4742856 | — | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL4779739 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL4782149 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL4764468 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL4754193 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL4750587 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL4741142 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL4747978 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL4796647 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL4785434 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL4749824 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL4778418 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL4784414 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL4762226 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL4744007 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL4764557 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL4760655 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL4780470 | — | Ki | = | 131.83 | nM | 6.88 |
| CHEMBL4763106 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL4790020 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL4748379 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL4751063 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL4748107 | — | Ki | = | 245.47 | nM | 6.61 |