Assay Detail
Binding
CHEMBL4685403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-methylspiperone from recombinant human D2 receptor expressed in CHOK1 cell membranes measured after 60 mins by microbeta counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.89 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747225 | — | — | 1 | 9.70 |
| CHEMBL4795995 | — | — | 1 | 9.35 |
| CHEMBL4747978 | — | — | 1 | 9.20 |
| CHEMBL4759492 | — | — | 1 | 9.03 |
| CHEMBL4764006 | — | — | 1 | 8.91 |
| CHEMBL4754193 | — | — | 1 | 8.85 |
| CHEMBL4748379 | — | — | 1 | 8.76 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.73 |
| CHEMBL4760655 | — | — | 1 | 8.59 |
| CHEMBL4744007 | — | — | 1 | 8.51 |
| CHEMBL4753094 | — | — | 1 | 8.25 |
| CHEMBL4751063 | — | — | 1 | 8.08 |
| CHEMBL4780470 | — | — | 1 | 8.05 |
| CHEMBL4742856 | — | — | 1 | 8.04 |
| CHEMBL4785434 | — | — | 1 | 7.91 |
| CHEMBL4763085 | — | — | 1 | 7.85 |
| CHEMBL4778418 | — | — | 1 | 7.82 |
| CHEMBL4764468 | — | — | 1 | 7.79 |
| CHEMBL4762226 | — | — | 1 | 7.75 |
| CHEMBL4793608 | — | — | 1 | 7.70 |
| CHEMBL4754138 | — | — | 1 | 7.69 |
| CHEMBL4784414 | — | — | 1 | 7.62 |
| CHEMBL4750664 | — | — | 1 | 7.50 |
| CHEMBL4776225 | — | — | 1 | 7.49 |
| CHEMBL4763106 | — | — | 1 | 7.46 |
| CHEMBL4749824 | — | — | 1 | 7.42 |
| CHEMBL4790020 | — | — | 1 | 7.41 |
| CHEMBL4782149 | — | — | 1 | 7.36 |
| CHEMBL4775997 | — | — | 1 | 7.25 |
| CHEMBL4764557 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747225 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL4795995 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL4747978 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL4759492 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL4764006 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL4754193 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL4748379 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL4760655 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL4744007 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL4753094 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL4751063 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL4780470 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL4742856 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL4785434 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL4763085 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL4778418 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL4764468 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL4762226 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL4793608 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL4754138 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL4784414 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL4750664 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL4776225 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL4763106 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL4749824 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL4790020 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL4782149 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL4775997 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL4784228 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL4764557 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL4758402 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL4741142 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4748107 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL4779739 | — | Ki | = | 104.71 | nM | 6.98 |
| CHEMBL4750587 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL4796647 | — | Ki | = | 323.59 | nM | 6.49 |