Assay Detail
ADMET
CHEMBL4685990
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Cytotoxicity against African green monkey COS7 cells assessed as reduction in cell mass measured after 72 hrs by crystal violet staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Chlorocebus aethiops |
| Cell Type | COS-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.92 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793264 | — | — | 1 | 5.22 |
| CHEMBL279301 | — | — | 1 | 5.06 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793264 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL279301 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 34000.0 | nM | 4.47 |