Assay Detail
Binding
CHEMBL4686048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected insect cells using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.60 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.21 |
| CHEMBL4749443 | — | — | 1 | 5.83 |
| CHEMBL4777009 | — | — | 1 | 5.30 |
| CHEMBL4757836 | — | — | 1 | 5.04 |
| CHEMBL4788251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4749443 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4777009 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL4757836 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4788251 | — | IC50 | > | 10000.0 | nM | - |