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Assay Detail

CHEMBL4686241

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at 5HT2A receptor (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy.
Zhu C,Li X,Zhao B,Peng W,Li W,Fu W
Eur J Med Chem (2020) 193 : 112214 -112214
PubMed 32182489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 9.02 9.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85 RISPERIDONE 4.0 1 9.77
CHEMBL42 CLOZAPINE 4.0 1 8.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85 RISPERIDONE Ki = 0.17 nM 9.77
CHEMBL42 CLOZAPINE Ki = 5.35 nM 8.27