Assay Detail
Functional
CHEMBL4686335
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Cytotoxicity against human L-363 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | L-363 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.63 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 9.74 |
| CHEMBL4790597 | — | — | 1 | 9.50 |
| CHEMBL4765060 | — | — | 1 | 8.79 |
| CHEMBL4745937 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 0.181 | nM | 9.74 |
| CHEMBL4790597 | — | IC50 | = | 0.316 | nM | 9.50 |
| CHEMBL4765060 | — | IC50 | = | 1.608 | nM | 8.79 |
| CHEMBL4745937 | — | IC50 | = | 339.0 | nM | 6.47 |