Assay Detail
Functional
CHEMBL4686452
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Cytotoxicity against human SW-620 cells assessed as reduction in cell viability after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.16 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 7.70 |
| CHEMBL4751149 | — | — | 1 | 7.52 |
| CHEMBL4784350 | — | — | 1 | 6.68 |
| CHEMBL499248 | — | — | 1 | 6.55 |
| CHEMBL4748310 | — | — | 1 | 6.19 |
| CHEMBL4756701 | — | — | 1 | 6.00 |
| CHEMBL4796068 | — | — | 1 | 5.94 |
| CHEMBL4800124 | — | — | 1 | 5.18 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.16 |
| CHEMBL4777936 | — | — | 1 | 4.66 |
| CHEMBL4794037 | — | — | 1 | - |
| CHEMBL4762468 | — | — | 1 | - |
| CHEMBL4790975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4751149 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4784350 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL499248 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4748310 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4756701 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4796068 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4800124 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL4777936 | — | IC50 | = | 21920.0 | nM | 4.66 |
| CHEMBL4794037 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4762468 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4790975 | — | IC50 | > | 200000.0 | nM | - |