Assay Detail
Functional
CHEMBL4686629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tetrahydroquinoline-based reversible LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.18 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776575 | — | — | 1 | 5.25 |
| CHEMBL4776923 | — | — | 1 | 5.24 |
| CHEMBL4798849 | — | — | 1 | 5.23 |
| CHEMBL4742362 | — | — | 1 | 5.18 |
| CHEMBL4762799 | — | — | 1 | 5.16 |
| CHEMBL4742730 | — | — | 1 | 5.02 |
| CHEMBL4788415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776575 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL4776923 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4798849 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL4742362 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL4762799 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL4742730 | — | IC50 | = | 9490.0 | nM | 5.02 |
| CHEMBL4788415 | — | IC50 | > | 30000.0 | nM | - |