Assay Detail
Binding
CHEMBL4686965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Norovirus GII.4 C-terminal His6-tagged RNA-dependent RNA polymerase in Escherichia coli assessed as decrease in GTP incorporation incubated for 10 mins by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Norovirus GII.4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.17 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746670 | — | — | 1 | 5.30 |
| CHEMBL1303854 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746670 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1303854 | — | IC50 | = | 9200.0 | nM | 5.04 |