Assay Detail
Functional
CHEMBL4686972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against murine Norovirus infected in mouse RAW264.7 cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Norovirus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.27 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079082 | — | — | 1 | 8.15 |
| CHEMBL4765106 | — | — | 1 | 8.15 |
| CHEMBL4744476 | — | — | 1 | 7.62 |
| CHEMBL4792425 | — | — | 1 | 7.46 |
| CHEMBL2031678 | — | — | 1 | 4.96 |
| CHEMBL98933 | — | — | 1 | - |
| CHEMBL3337572 | — | — | 1 | - |
| CHEMBL4761971 | — | — | 1 | - |
| CHEMBL4744506 | — | — | 1 | - |
| CHEMBL4785972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079082 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4765106 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4744476 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4792425 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2031678 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL98933 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL3337572 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL4761971 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4744506 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4785972 | — | EC50 | > | 10000.0 | nM | - |