Assay Detail
Functional
CHEMBL4686979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells harboring KRAS G13D/BRAF G464V mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.26 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | 4.0 | 1 | 7.75 |
| CHEMBL4743982 | — | — | 1 | 7.47 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.09 |
| CHEMBL4791772 | — | — | 1 | 7.03 |
| CHEMBL4776354 | — | — | 1 | 6.89 |
| CHEMBL3264002 | AVUTOMETINIB | 3.0 | 1 | 6.77 |
| CHEMBL4762919 | — | — | 1 | 6.75 |
| CHEMBL4745811 | — | — | 1 | 6.70 |
| CHEMBL4792808 | — | — | 1 | 6.57 |
| CHEMBL4779971 | — | — | 1 | 6.51 |
| CHEMBL4741092 | — | — | 1 | 6.42 |
| CHEMBL4781475 | — | — | 1 | 6.07 |
| CHEMBL4746795 | — | — | 1 | 5.72 |
| CHEMBL4791245 | — | — | 1 | 5.66 |
| CHEMBL4796522 | — | — | 1 | 5.62 |
| CHEMBL4740885 | — | — | 1 | 5.61 |
| CHEMBL455983 | — | — | 1 | 5.54 |
| CHEMBL4745039 | — | — | 1 | 5.52 |
| CHEMBL4752434 | — | — | 1 | 5.50 |
| CHEMBL4778955 | — | — | 1 | 5.26 |
| CHEMBL4779702 | — | — | 1 | 5.11 |
| CHEMBL4747266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4743982 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4791772 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4776354 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3264002 | AVUTOMETINIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4762919 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4745811 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4792808 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4779971 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4741092 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4781475 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4746795 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4791245 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4796522 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4740885 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL455983 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4745039 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4752434 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4778955 | — | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL4779702 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL4747266 | — | IC50 | - | — | - |