Assay Detail
ADMET
CHEMBL4686990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 96 hrs by Celltiter-Glo assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.40 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745811 | — | — | 1 | 5.71 |
| CHEMBL455983 | — | — | 1 | 5.70 |
| CHEMBL4791772 | — | — | 1 | 5.56 |
| CHEMBL4743982 | — | — | 1 | 5.25 |
| CHEMBL3264002 | AVUTOMETINIB | 3.0 | 1 | 4.76 |
| CHEMBL4791245 | — | — | 1 | - |
| CHEMBL4746795 | — | — | 1 | - |
| CHEMBL4752434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745811 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL455983 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4791772 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4743982 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL3264002 | AVUTOMETINIB | IC50 | = | 17270.0 | nM | 4.76 |
| CHEMBL4791245 | — | IC50 | - | — | - | |
| CHEMBL4746795 | — | IC50 | - | — | - | |
| CHEMBL4752434 | — | IC50 | - | — | - |